BDBM50363156 CHEMBL1946998
SMILES: OC(=O)c1ccc(\C=C\C(=O)c2ccc3ccccc3c2)cc1
InChI Key: InChIKey=OCHBFKMZYRIYDH-KPKJPENVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Tyrosine Phosphatase PTPB (Mycobacterium tuberculosis) | BDBM50363156 (CHEMBL1946998) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Santa Catarina Curated by ChEMBL | Assay Description Competitive inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by Lineweaver-Burk plot an... | J Med Chem 55: 390-402 (2012) Article DOI: 10.1021/jm2012062 BindingDB Entry DOI: 10.7270/Q2445MZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-tyrosine phosphatase 1B (Homo sapiens (Human)) | BDBM50363156 (CHEMBL1946998) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.09E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Santa Catarina Curated by ChEMBL | Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21 DE3 using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetr... | J Med Chem 55: 390-402 (2012) Article DOI: 10.1021/jm2012062 BindingDB Entry DOI: 10.7270/Q2445MZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable low molecular weight protein-tyrosine-phosphatase (Mycobacterium tuberculosis) | BDBM50363156 (CHEMBL1946998) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Santa Catarina Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry | J Med Chem 55: 390-402 (2012) Article DOI: 10.1021/jm2012062 BindingDB Entry DOI: 10.7270/Q2445MZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Tyrosine Phosphatase PTPB (Mycobacterium tuberculosis) | BDBM50363156 (CHEMBL1946998) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Santa Catarina Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry | J Med Chem 55: 390-402 (2012) Article DOI: 10.1021/jm2012062 BindingDB Entry DOI: 10.7270/Q2445MZ4 | |||||||||||
More data for this Ligand-Target Pair |