BDBM50363398 CHEMBL1946171

SMILES: Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2ccc(Oc3ccnc(c3)-c3c[nH]c(n3)C(F)(F)F)cc12

InChI Key: InChIKey=HRCJMYWMDPFSHS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50363398   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50363398 (CHEMBL1946171) Show SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2ccc(Oc3ccnc(c3)-c3c[nH]c(n3)C(F)(F)F)cc12 Show InChI InChI=1S/C24H16F6N6O/c1-36-20-11-15(37-16-8-9-31-18(10-16)19-12-32-21(34-19)24(28,29)30)6-7-17(20)35-22(36)33-14-4-2-13(3-5-14)23(25,26)27/h2-12H,1H3,(H,32,34)(H,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of wild-type B-Raf				Bioorg Med Chem Lett 22: 789-92 (2012) Article DOI: 10.1016/j.bmcl.2011.11.060 BindingDB Entry DOI: 10.7270/Q2SQ90VM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50363398 (CHEMBL1946171) Show SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2ccc(Oc3ccnc(c3)-c3c[nH]c(n3)C(F)(F)F)cc12 Show InChI InChI=1S/C24H16F6N6O/c1-36-20-11-15(37-16-8-9-31-18(10-16)19-12-32-21(34-19)24(28,29)30)6-7-17(20)35-22(36)33-14-4-2-13(3-5-14)23(25,26)27/h2-12H,1H3,(H,32,34)(H,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 22: 789-92 (2012) Article DOI: 10.1016/j.bmcl.2011.11.060 BindingDB Entry DOI: 10.7270/Q2SQ90VM
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50363398 (CHEMBL1946171) Show SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2ccc(Oc3ccnc(c3)-c3c[nH]c(n3)C(F)(F)F)cc12 Show InChI InChI=1S/C24H16F6N6O/c1-36-20-11-15(37-16-8-9-31-18(10-16)19-12-32-21(34-19)24(28,29)30)6-7-17(20)35-22(36)33-14-4-2-13(3-5-14)23(25,26)27/h2-12H,1H3,(H,32,34)(H,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of C-Raf				Bioorg Med Chem Lett 22: 789-92 (2012) Article DOI: 10.1016/j.bmcl.2011.11.060 BindingDB Entry DOI: 10.7270/Q2SQ90VM
					More data for this Ligand-Target Pair