BindingDB PrimarySearch

BDBM50363494 5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-diol) (4)::CHEMBL374829

SMILES: Oc1c(O)c(Br)c(Cc2c(Br)c(O)c(O)c(Br)c2Br)c(Br)c1Br

InChI Key: InChIKey=AMKNSMNMEAMKDN-UHFFFAOYSA-N

Data: 4 KI 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50363494
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.78E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Artvin£oruh University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 6 esterase activity using 4-nitrophenylacetate as substrate				Bioorg Med Chem Lett 22: 1352-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.069 BindingDB Entry DOI: 10.7270/Q2WH2QF4
Artvin£oruh University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.15E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Artvin£oruh University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 esterase activity using 4-nitrophenylacetate as substrate				Bioorg Med Chem Lett 22: 1352-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.069 BindingDB Entry DOI: 10.7270/Q2WH2QF4
Artvin£oruh University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Artvin£oruh University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 4 esterase activity using 4-nitrophenylacetate as substrate				Bioorg Med Chem Lett 22: 1352-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.069 BindingDB Entry DOI: 10.7270/Q2WH2QF4
Artvin£oruh University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.51E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Artvin£oruh University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate				Bioorg Med Chem Lett 22: 1352-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.069 BindingDB Entry DOI: 10.7270/Q2WH2QF4
Artvin£oruh University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1C (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of SHP1 using OMFP as substrate after 3 mins				Bioorg Med Chem Lett 22: 2827-32 (2012) Article DOI: 10.1016/j.bmcl.2012.02.074 BindingDB Entry DOI: 10.7270/Q28K7B33
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR) (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of LAR using OMFP as substrate after 3 mins				Bioorg Med Chem Lett 22: 2827-32 (2012) Article DOI: 10.1016/j.bmcl.2012.02.074 BindingDB Entry DOI: 10.7270/Q28K7B33
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of SHP2 using OMFP as substrate after 3 mins				Bioorg Med Chem Lett 22: 2827-32 (2012) Article DOI: 10.1016/j.bmcl.2012.02.074 BindingDB Entry DOI: 10.7270/Q28K7B33
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of TCPTP after 3 mins				Bioorg Med Chem Lett 22: 2827-32 (2012) Article DOI: 10.1016/j.bmcl.2012.02.074 BindingDB Entry DOI: 10.7270/Q28K7B33
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	566	n/a	n/a	n/a	n/a	n/a	n/a
Jilin Province Academy of Traditional Chinese Medicine and Materia Medica Curated by ChEMBL					Assay Description Inhibition of human muscle recombinant aldose reductase by spectrophotometry				J Nat Prod 68: 620-2 (2005) Article DOI: 10.1021/np040199j BindingDB Entry DOI: 10.7270/Q2BZ68TQ
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.83E+4	n/a	n/a	n/a	n/a	n/a	n/a
Atat�rk University					Assay Description Carbonic anhydrase activity was assayed by following the hydration of CO2 according to our previous studies [Soyut et al., Protein Pept. Lett., 15:52...				J Enzyme Inhib Med Chem 27: 43-50 (2012) Article DOI: 10.3109/14756366.2011.574131 BindingDB Entry DOI: 10.7270/Q2CR5S75
Atat�rk University					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50363494 (5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-d...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant PTB1B using pNPP as substrate after 3 mins				Bioorg Med Chem Lett 22: 2827-32 (2012) Article DOI: 10.1016/j.bmcl.2012.02.074 BindingDB Entry DOI: 10.7270/Q28K7B33
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair