Found 3 hits for monomerid = 50363947 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50363947
(CHEMBL1951772)Show SMILES O[C@]1(CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1ccncn1 |r,wU:4.7,wD:10.13,1.0,(-5.51,-34.96,;-4.74,-36.3,;-3.93,-37.62,;-2.4,-37.59,;-1.65,-36.24,;-2.45,-34.92,;-3.99,-34.95,;-.11,-36.21,;.81,-37.43,;2.27,-36.93,;2.24,-35.39,;.76,-34.94,;3.56,-34.6,;4.9,-35.36,;4.92,-36.9,;6.23,-34.57,;7.57,-35.32,;8.9,-34.54,;8.88,-33,;10.24,-35.29,;10.25,-36.83,;11.59,-37.58,;12.92,-36.8,;12.89,-35.25,;11.55,-34.5,;14.21,-34.46,;15.56,-35.21,;14.19,-32.92,;15.54,-33.68,;-6.28,-36.34,;-7.08,-35.03,;-8.61,-35.06,;-9.36,-36.41,;-8.56,-37.73,;-7.02,-37.7,)| Show InChI InChI=1S/C24H28F3N5O3/c25-24(26,27)17-3-1-2-16(12-17)22(34)29-13-21(33)31-18-7-11-32(14-18)19-4-8-23(35,9-5-19)20-6-10-28-15-30-20/h1-3,6,10,12,15,18-19,35H,4-5,7-9,11,13-14H2,(H,29,34)(H,31,33)/t18-,19-,23-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMC after 30 mins by gamma counter |
ACS Med Chem Lett 2: 450-454 (2011)
Article DOI: 10.1021/ml200030q
BindingDB Entry DOI: 10.7270/Q2WD4116 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50363947
(CHEMBL1951772)Show SMILES O[C@]1(CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1ccncn1 |r,wU:4.7,wD:10.13,1.0,(-5.51,-34.96,;-4.74,-36.3,;-3.93,-37.62,;-2.4,-37.59,;-1.65,-36.24,;-2.45,-34.92,;-3.99,-34.95,;-.11,-36.21,;.81,-37.43,;2.27,-36.93,;2.24,-35.39,;.76,-34.94,;3.56,-34.6,;4.9,-35.36,;4.92,-36.9,;6.23,-34.57,;7.57,-35.32,;8.9,-34.54,;8.88,-33,;10.24,-35.29,;10.25,-36.83,;11.59,-37.58,;12.92,-36.8,;12.89,-35.25,;11.55,-34.5,;14.21,-34.46,;15.56,-35.21,;14.19,-32.92,;15.54,-33.68,;-6.28,-36.34,;-7.08,-35.03,;-8.61,-35.06,;-9.36,-36.41,;-8.56,-37.73,;-7.02,-37.7,)| Show InChI InChI=1S/C24H28F3N5O3/c25-24(26,27)17-3-1-2-16(12-17)22(34)29-13-21(33)31-18-7-11-32(14-18)19-4-8-23(35,9-5-19)20-6-10-28-15-30-20/h1-3,6,10,12,15,18-19,35H,4-5,7-9,11,13-14H2,(H,29,34)(H,31,33)/t18-,19-,23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of dofetidine from human Erg |
ACS Med Chem Lett 2: 450-454 (2011)
Article DOI: 10.1021/ml200030q
BindingDB Entry DOI: 10.7270/Q2WD4116 |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50363947
(CHEMBL1951772)Show SMILES O[C@]1(CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1ccncn1 |r,wU:4.7,wD:10.13,1.0,(-5.51,-34.96,;-4.74,-36.3,;-3.93,-37.62,;-2.4,-37.59,;-1.65,-36.24,;-2.45,-34.92,;-3.99,-34.95,;-.11,-36.21,;.81,-37.43,;2.27,-36.93,;2.24,-35.39,;.76,-34.94,;3.56,-34.6,;4.9,-35.36,;4.92,-36.9,;6.23,-34.57,;7.57,-35.32,;8.9,-34.54,;8.88,-33,;10.24,-35.29,;10.25,-36.83,;11.59,-37.58,;12.92,-36.8,;12.89,-35.25,;11.55,-34.5,;14.21,-34.46,;15.56,-35.21,;14.19,-32.92,;15.54,-33.68,;-6.28,-36.34,;-7.08,-35.03,;-8.61,-35.06,;-9.36,-36.41,;-8.56,-37.73,;-7.02,-37.7,)| Show InChI InChI=1S/C24H28F3N5O3/c25-24(26,27)17-3-1-2-16(12-17)22(34)29-13-21(33)31-18-7-11-32(14-18)19-4-8-23(35,9-5-19)20-6-10-28-15-30-20/h1-3,6,10,12,15,18-19,35H,4-5,7-9,11,13-14H2,(H,29,34)(H,31,33)/t18-,19-,23-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 30 mins |
ACS Med Chem Lett 2: 450-454 (2011)
Article DOI: 10.1021/ml200030q
BindingDB Entry DOI: 10.7270/Q2WD4116 |
More data for this
Ligand-Target Pair | |
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