BindingDB PrimarySearch

BDBM50366238 CHEMBL1961796

SMILES: CCOC(=O)N1CCC(CN(Cc2ccc(s2)[N+]([O-])=O)Cc2ccc(Cl)cc2)C1

InChI Key: InChIKey=MMJJNHOIVCGAAP-UHFFFAOYSA-N

Data: 5 IC50 1 Kd 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50366238
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nuclear receptor subfamily 1 group D member 1 (Homo sapiens (Human))	BDBM50366238 (CHEMBL1961796) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Increased REV-ERB-alpha LBD dependent repressor activity in HEK293 cell reporter assay				Nature 485: 62-68 (2012) Article DOI: 10.1038/nature11030 BindingDB Entry DOI: 10.7270/Q2445N00
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group D member 2 (Homo sapiens (Human))	BDBM50366238 (CHEMBL1961796) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Increased REV-ERB-beta LBD dependent repressor activity in HEK293 cell reporter assay				Nature 485: 62-68 (2012) Article DOI: 10.1038/nature11030 BindingDB Entry DOI: 10.7270/Q2445N00
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group D member 1 (Homo sapiens (Human))	BDBM50366238 (CHEMBL1961796) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description REV-ERB-alpha mediated transcriptional suppression at Bmal1 promoter in HEK293 cell reporter assay				Nature 485: 62-68 (2012) Article DOI: 10.1038/nature11030 BindingDB Entry DOI: 10.7270/Q2445N00
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group D member 1 (Homo sapiens (Human))	BDBM50366238 (CHEMBL1961796) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Agonist activity at Rev-Erbalpha expressed in HEK293 cells coexpressing BamII promoter assessed as repression of transcription after 24 hrs by dual-G...				Bioorg Med Chem Lett 22: 4413-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.126 BindingDB Entry DOI: 10.7270/Q2D21ZPZ
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50366238 (CHEMBL1961796) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to LXRalpha (unknown origin) by radioligand displacement assay				J Med Chem 56: 4729-37 (2013) Article DOI: 10.1021/jm400458q BindingDB Entry DOI: 10.7270/Q20Z74PJ
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group D member 1 (Homo sapiens (Human))	BDBM50366238 (CHEMBL1961796) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at biotinylated REV-ERBalpha (unknown origin) assessed as increase in biotinylated NCOR peptide recruitment after 1 hr by FRET assay				J Med Chem 56: 4729-37 (2013) Article DOI: 10.1021/jm400458q BindingDB Entry DOI: 10.7270/Q20Z74PJ
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group D member 1 (Homo sapiens (Human))	BDBM50366238 (CHEMBL1961796) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Agonist activity at Rev-Erbalpha expressed in HEK293 cells coexpressing Gal4 ligand binding domain assessed as inhibition of transcription after 24 h...				Bioorg Med Chem Lett 22: 4413-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.126 BindingDB Entry DOI: 10.7270/Q2D21ZPZ
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group D member 1 (Homo sapiens (Human))	BDBM50366238 (CHEMBL1961796) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Dissociation constant for binding to REV-ERB-alpha by circular dichroism				Nature 485: 62-68 (2012) Article DOI: 10.1038/nature11030 BindingDB Entry DOI: 10.7270/Q2445N00
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair