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BDBM50370227 CHEMBL610609

SMILES: Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)C(COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](CO)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12

InChI Key: InChIKey=SHVMQRXBUZMNLU-YERQZEEXSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50370227   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RNase L


(Mus musculus)		BDBM50370227
PNG
(CHEMBL610609)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)C(COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](CO)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 |r|
Show InChI InChI=1S/C30H34N24O16P2/c31-19-10-22(40-4-37-19)52(28(43-10)46-49-34)25-16(59)13(56)8(67-25)2-64-71(60,61)70-18-15(58)9(68-27(18)54-24-12(21(33)39-6-42-24)45-30(54)48-51-36)3-65-72(62,63)69-17-14(57)7(1-55)66-26(17)53-23-11(20(32)38-5-41-23)44-29(53)47-50-35/h4-9,13-18,25-27,55-59H,1-3H2,(H,60,61)(H,62,63)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)/t7-,8-,9?,13-,14-,15-,16-,17-,18-,25?,26?,27?/m1/s1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver

J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair