BDBM50375606 CHEMBL76084

SMILES: Cc1cccc(Cl)c1Nc1ccccc1CC(O)=O

InChI Key: InChIKey=PQOGEFXKUUCLAX-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50375606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclooxygenase (Homo sapiens (Human))	BDBM50375606 (CHEMBL76084) Show SMILES Cc1cccc(Cl)c1Nc1ccccc1CC(O)=O Show InChI InChI=1S/C15H14ClNO2/c1-10-5-4-7-12(16)15(10)17-13-8-3-2-6-11(13)9-14(18)19/h2-8,17H,9H2,1H3,(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Institute for Chemical Biology Curated by ChEMBL					Assay Description Inhibition of human COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid				J Biol Chem 282: 16379-90 (2007) Article DOI: 10.1074/jbc.M609883200 BindingDB Entry DOI: 10.7270/Q2X92C5N
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM50375606 (CHEMBL76084) Show SMILES Cc1cccc(Cl)c1Nc1ccccc1CC(O)=O Show InChI InChI=1S/C15H14ClNO2/c1-10-5-4-7-12(16)15(10)17-13-8-3-2-6-11(13)9-14(18)19/h2-8,17H,9H2,1H3,(H,18,19)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Institute for Chemical Biology Curated by ChEMBL					Assay Description Inhibition of ovine COX1 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid				J Biol Chem 282: 16379-90 (2007) Article DOI: 10.1074/jbc.M609883200 BindingDB Entry DOI: 10.7270/Q2X92C5N
					More data for this Ligand-Target Pair
Cyclooxygenase (Bos taurus)	BDBM50375606 (CHEMBL76084) Show SMILES Cc1cccc(Cl)c1Nc1ccccc1CC(O)=O Show InChI InChI=1S/C15H14ClNO2/c1-10-5-4-7-12(16)15(10)17-13-8-3-2-6-11(13)9-14(18)19/h2-8,17H,9H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+9	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Limited Curated by ChEMBL					Assay Description In vitro inhibition of bovine prostaglandin G/H synthase, using bovine seminal vesicle microsomal preparations; IC50 in umol/L				J Med Chem 33: 2358-68 (1990) BindingDB Entry DOI: 10.7270/Q2251MD5
					More data for this Ligand-Target Pair
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse))	BDBM50375606 (CHEMBL76084) Show SMILES Cc1cccc(Cl)c1Nc1ccccc1CC(O)=O Show InChI InChI=1S/C15H14ClNO2/c1-10-5-4-7-12(16)15(10)17-13-8-3-2-6-11(13)9-14(18)19/h2-8,17H,9H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Institute for Chemical Biology Curated by ChEMBL					Assay Description Inhibition of mouse COX2 for 20 mins pre-incubated before addition of [1-14C]arachidonic acid				J Biol Chem 282: 16379-90 (2007) Article DOI: 10.1074/jbc.M609883200 BindingDB Entry DOI: 10.7270/Q2X92C5N
					More data for this Ligand-Target Pair
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse))	BDBM50375606 (CHEMBL76084) Show SMILES Cc1cccc(Cl)c1Nc1ccccc1CC(O)=O Show InChI InChI=1S/C15H14ClNO2/c1-10-5-4-7-12(16)15(10)17-13-8-3-2-6-11(13)9-14(18)19/h2-8,17H,9H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Institute for Chemical Biology Curated by ChEMBL					Assay Description Inhibition of mouse COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid				J Biol Chem 282: 16379-90 (2007) Article DOI: 10.1074/jbc.M609883200 BindingDB Entry DOI: 10.7270/Q2X92C5N
					More data for this Ligand-Target Pair