BDBM50375993 CHEMBL259252

SMILES: COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CCC3)c2cc1OC

InChI Key: InChIKey=BYYYCNUDMZSOGS-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50375993   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50375993 (CHEMBL259252) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CCC3)c2cc1OC Show InChI InChI=1S/C26H24N2O4/c1-30-24-14-21-22(15-25(24)31-2)27-12-11-23(21)32-18-9-10-19-16(13-18)5-3-8-20(19)26(29)28-17-6-4-7-17/h3,5,8-15,17H,4,6-7H2,1-2H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50375993 (CHEMBL259252) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CCC3)c2cc1OC Show InChI InChI=1S/C26H24N2O4/c1-30-24-14-21-22(15-25(24)31-2)27-12-11-23(21)32-18-9-10-19-16(13-18)5-3-8-20(19)26(29)28-17-6-4-7-17/h3,5,8-15,17H,4,6-7H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of KDR				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50375993 (CHEMBL259252) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CCC3)c2cc1OC Show InChI InChI=1S/C26H24N2O4/c1-30-24-14-21-22(15-25(24)31-2)27-12-11-23(21)32-18-9-10-19-16(13-18)5-3-8-20(19)26(29)28-17-6-4-7-17/h3,5,8-15,17H,4,6-7H2,1-2H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Lck				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50375993 (CHEMBL259252) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CCC3)c2cc1OC Show InChI InChI=1S/C26H24N2O4/c1-30-24-14-21-22(15-25(24)31-2)27-12-11-23(21)32-18-9-10-19-16(13-18)5-3-8-20(19)26(29)28-17-6-4-7-17/h3,5,8-15,17H,4,6-7H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.14	n/a	n/a	n/a	n/a	n/a	n/a
Lanzhou University Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 after 60 mins				J Mol Graph Model 27: 642-54 (2008) Article DOI: 10.1016/j.jmgm.2008.10.006 BindingDB Entry DOI: 10.7270/Q2C24XNX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50375993 (CHEMBL259252) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CCC3)c2cc1OC Show InChI InChI=1S/C26H24N2O4/c1-30-24-14-21-22(15-25(24)31-2)27-12-11-23(21)32-18-9-10-19-16(13-18)5-3-8-20(19)26(29)28-17-6-4-7-17/h3,5,8-15,17H,4,6-7H2,1-2H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50375993 (CHEMBL259252) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CCC3)c2cc1OC Show InChI InChI=1S/C26H24N2O4/c1-30-24-14-21-22(15-25(24)31-2)27-12-11-23(21)32-18-9-10-19-16(13-18)5-3-8-20(19)26(29)28-17-6-4-7-17/h3,5,8-15,17H,4,6-7H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				J Med Chem 51: 1649-67 (2008) Article DOI: 10.1021/jm701097z BindingDB Entry DOI: 10.7270/Q29C6Z8N
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50375993 (CHEMBL259252) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CCC3)c2cc1OC Show InChI InChI=1S/C26H24N2O4/c1-30-24-14-21-22(15-25(24)31-2)27-12-11-23(21)32-18-9-10-19-16(13-18)5-3-8-20(19)26(29)28-17-6-4-7-17/h3,5,8-15,17H,4,6-7H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora A				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair