BDBM50376002 CHEMBL411284

SMILES: COc1cc2ncnc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC

InChI Key: InChIKey=JLBAXNKYJZOYGQ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50376002   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM50376002 (CHEMBL411284) Show SMILES COc1cc2ncnc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-21-11-19-20(12-22(21)30-2)25-13-26-24(19)31-16-8-9-17-14(10-16)4-3-5-18(17)23(28)27-15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50376002 (CHEMBL411284) Show SMILES COc1cc2ncnc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-21-11-19-20(12-22(21)30-2)25-13-26-24(19)31-16-8-9-17-14(10-16)4-3-5-18(17)23(28)27-15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of KDR				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50376002 (CHEMBL411284) Show SMILES COc1cc2ncnc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-21-11-19-20(12-22(21)30-2)25-13-26-24(19)31-16-8-9-17-14(10-16)4-3-5-18(17)23(28)27-15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.88	n/a	n/a	n/a	n/a	n/a	n/a
Lanzhou University Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 after 60 mins				J Mol Graph Model 27: 642-54 (2008) Article DOI: 10.1016/j.jmgm.2008.10.006 BindingDB Entry DOI: 10.7270/Q2C24XNX
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50376002 (CHEMBL411284) Show SMILES COc1cc2ncnc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-21-11-19-20(12-22(21)30-2)25-13-26-24(19)31-16-8-9-17-14(10-16)4-3-5-18(17)23(28)27-15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50376002 (CHEMBL411284) Show SMILES COc1cc2ncnc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-21-11-19-20(12-22(21)30-2)25-13-26-24(19)31-16-8-9-17-14(10-16)4-3-5-18(17)23(28)27-15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora A				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50376002 (CHEMBL411284) Show SMILES COc1cc2ncnc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-21-11-19-20(12-22(21)30-2)25-13-26-24(19)31-16-8-9-17-14(10-16)4-3-5-18(17)23(28)27-15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2				J Med Chem 51: 1668-80 (2008) Article DOI: 10.1021/jm701098w BindingDB Entry DOI: 10.7270/Q2F47Q0C
					More data for this Ligand-Target Pair