BDBM50378541 CHEMBL570321

SMILES: CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(c2)C(O)=O)C1=O

InChI Key: InChIKey=UIPUZDWBISFWKB-NVNXTCNLSA-N

Data: 4 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50378541   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Integrin alpha M/beta-2 (Homo sapiens (Human))	BDBM50378541 (CHEMBL570321) Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(c2)C(O)=O)C1=O Show InChI InChI=1S/C19H14ClNO7S/c1-2-27-16(22)9-21-17(23)15(29-19(21)26)8-11-4-6-14(28-11)10-3-5-13(20)12(7-10)18(24)25/h3-8H,2,9H2,1H3,(H,24,25)/b15-8-	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
Department of Medicine and University of Miami Curated by ChEMBL					Assay Description Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen				Bioorg Med Chem Lett 19: 6902-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.077 BindingDB Entry DOI: 10.7270/Q2NS0VV0
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50378541 (CHEMBL570321) Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(c2)C(O)=O)C1=O Show InChI InChI=1S/C19H14ClNO7S/c1-2-27-16(22)9-21-17(23)15(29-19(21)26)8-11-4-6-14(28-11)10-3-5-13(20)12(7-10)18(24)25/h3-8H,2,9H2,1H3,(H,24,25)/b15-8-	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<3.16E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 5 mins by liquid scintillation counting ...				J Med Chem 59: 8757-8770 (2016) Article DOI: 10.1021/acs.jmedchem.6b01058
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50378541 (CHEMBL570321) Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(c2)C(O)=O)C1=O Show InChI InChI=1S/C19H14ClNO7S/c1-2-27-16(22)9-21-17(23)15(29-19(21)26)8-11-4-6-14(28-11)10-3-5-13(20)12(7-10)18(24)25/h3-8H,2,9H2,1H3,(H,24,25)/b15-8-	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 5 mins by liquid scintillation counting ...				J Med Chem 59: 8757-8770 (2016) Article DOI: 10.1021/acs.jmedchem.6b01058
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50378541 (CHEMBL570321) Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(c2)C(O)=O)C1=O Show InChI InChI=1S/C19H14ClNO7S/c1-2-27-16(22)9-21-17(23)15(29-19(21)26)8-11-4-6-14(28-11)10-3-5-13(20)12(7-10)18(24)25/h3-8H,2,9H2,1H3,(H,24,25)/b15-8-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 5 mins by liquid scintillation counting ...				J Med Chem 59: 8757-8770 (2016) Article DOI: 10.1021/acs.jmedchem.6b01058
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 2 (Homo sapiens (Human))	BDBM50378541 (CHEMBL570321) Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(c2)C(O)=O)C1=O Show InChI InChI=1S/C19H14ClNO7S/c1-2-27-16(22)9-21-17(23)15(29-19(21)26)8-11-4-6-14(28-11)10-3-5-13(20)12(7-10)18(24)25/h3-8H,2,9H2,1H3,(H,24,25)/b15-8-	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 5 mins by liquid scintillation counting ...				J Med Chem 59: 8757-8770 (2016) Article DOI: 10.1021/acs.jmedchem.6b01058
					More data for this Ligand-Target Pair