BDBM50379353 CHEMBL2011929

SMILES: COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C(C)C)c2[nH]1

InChI Key: InChIKey=VLQLXNFFVREKBK-UHFFFAOYSA-N

Data: 4 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50379353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM50379353 (CHEMBL2011929) Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C(C)C)c2[nH]1 Show InChI InChI=1S/C20H24BrN5O2/c1-12(2)20(27)23-10-4-9-22-16-15(21)11-24-19-17(16)25-18(26-19)13-5-7-14(28-3)8-6-13/h5-8,11-12H,4,9-10H2,1-3H3,(H,23,27)(H2,22,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of recombinant TBK1 using 5FAM-AhxKRRAL(ps)VASLPGL as substrate by microfluidic mobility shift assay				Bioorg Med Chem Lett 22: 2063-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.018 BindingDB Entry DOI: 10.7270/Q2WS8V74
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50379353 (CHEMBL2011929) Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C(C)C)c2[nH]1 Show InChI InChI=1S/C20H24BrN5O2/c1-12(2)20(27)23-10-4-9-22-16-15(21)11-24-19-17(16)25-18(26-19)13-5-7-14(28-3)8-6-13/h5-8,11-12H,4,9-10H2,1-3H3,(H,23,27)(H2,22,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of Aurora B kinase				Bioorg Med Chem Lett 22: 2063-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.018 BindingDB Entry DOI: 10.7270/Q2WS8V74
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50379353 (CHEMBL2011929) Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C(C)C)c2[nH]1 Show InChI InChI=1S/C20H24BrN5O2/c1-12(2)20(27)23-10-4-9-22-16-15(21)11-24-19-17(16)25-18(26-19)13-5-7-14(28-3)8-6-13/h5-8,11-12H,4,9-10H2,1-3H3,(H,23,27)(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 22: 2063-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.018 BindingDB Entry DOI: 10.7270/Q2WS8V74
					More data for this Ligand-Target Pair
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM50379353 (CHEMBL2011929) Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C(C)C)c2[nH]1 Show InChI InChI=1S/C20H24BrN5O2/c1-12(2)20(27)23-10-4-9-22-16-15(21)11-24-19-17(16)25-18(26-19)13-5-7-14(28-3)8-6-13/h5-8,11-12H,4,9-10H2,1-3H3,(H,23,27)(H2,22,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...				Bioorg Med Chem Lett 22: 2063-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.018 BindingDB Entry DOI: 10.7270/Q2WS8V74
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM50379353 (CHEMBL2011929) Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C(C)C)c2[nH]1 Show InChI InChI=1S/C20H24BrN5O2/c1-12(2)20(27)23-10-4-9-22-16-15(21)11-24-19-17(16)25-18(26-19)13-5-7-14(28-3)8-6-13/h5-8,11-12H,4,9-10H2,1-3H3,(H,23,27)(H2,22,24,25,26)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of Ikkepsilon using 5FAM-AKELDQGSLCTpSFVGTLQ-NH2 as substrate by microfluidic mobility shift assay				Bioorg Med Chem Lett 22: 2063-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.018 BindingDB Entry DOI: 10.7270/Q2WS8V74
					More data for this Ligand-Target Pair