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SMILES: Nc1nc2ccccc2c2n(Cc3ccccc3)c(CCCCCCc3nc4c(N)nc5ccccc5c4n3Cc3ccccc3)nc12

InChI Key: InChIKey=VZNBCXDUDOJOCE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50380492   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))		BDBM50380492
PNG
(CHEMBL2018890)
Show SMILES Nc1nc2ccccc2c2n(Cc3ccccc3)c(CCCCCCc3nc4c(N)nc5ccccc5c4n3Cc3ccccc3)nc12
Show InChI InChI=1S/C40H38N8/c41-39-35-37(29-19-11-13-21-31(29)43-39)47(25-27-15-5-3-6-16-27)33(45-35)23-9-1-2-10-24-34-46-36-38(48(34)26-28-17-7-4-8-18-28)30-20-12-14-22-32(30)44-40(36)42/h3-8,11-22H,1-2,9-10,23-26H2,(H2,41,43)(H2,42,44)
PDB

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antibodypedia
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.09E+4n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NFkappaB activation by sAP reporter gene assay

J Med Chem 55: 1106-16 (2012)


Article DOI: 10.1021/jm2010207
BindingDB Entry DOI: 10.7270/Q2VH5PVX
More data for this
Ligand-Target Pair