BDBM50380697 CHEMBL2017513

SMILES: CCOP(=O)(OCC)C(Cc1cccc(c1)C(F)(F)F)c1sc2ccccc2c1C

InChI Key: InChIKey=ZSBHNWQLZFHLRG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50380697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Canis lupus familiaris (Dog))	BDBM50380697 (CHEMBL2017513) Show SMILES CCOP(=O)(OCC)C(Cc1cccc(c1)C(F)(F)F)c1sc2ccccc2c1C Show InChI InChI=1S/C22H24F3O3PS/c1-4-27-29(26,28-5-2)19(14-16-9-8-10-17(13-16)22(23,24)25)21-15(3)18-11-6-7-12-20(18)30-21/h6-13,19H,4-5,14H2,1-3H3	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...				Bioorg Med Chem Lett 22: 2922-6 (2012) Article DOI: 10.1016/j.bmcl.2012.02.060 BindingDB Entry DOI: 10.7270/Q2TM7C48
					More data for this Ligand-Target Pair