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BDBM50380927 CHEMBL2016744

SMILES: FC(F)(F)CN([C@H]1CC[C@@]2(CC1)Cc1ccccc1C(=O)O2)C(=O)Nc1cnc(cn1)-c1ccccc1

InChI Key: InChIKey=DQBWVCDHPKHCRO-ZVWHWTBFSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50380927   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuropeptide Y receptor type 5


(Homo sapiens (Human))		BDBM50380927
PNG
(CHEMBL2016744)
Show SMILES FC(F)(F)CN([C@H]1CC[C@@]2(CC1)Cc1ccccc1C(=O)O2)C(=O)Nc1cnc(cn1)-c1ccccc1 |r,wU:6.5,9.23,(25.73,-7.24,;25.69,-8.78,;24.33,-9.51,;24.35,-8,;27,-9.58,;26.96,-11.12,;25.61,-11.86,;25.6,-13.39,;24.28,-14.16,;22.95,-13.39,;22.94,-11.85,;24.28,-11.09,;21.61,-12.62,;20.28,-13.39,;18.96,-12.61,;17.62,-13.38,;17.62,-14.93,;18.95,-15.69,;20.28,-14.93,;21.61,-15.7,;21.61,-17.24,;22.95,-14.93,;28.28,-11.93,;28.34,-13.47,;29.6,-11.14,;30.95,-11.9,;32.27,-11.13,;33.61,-11.89,;33.61,-13.44,;32.27,-14.21,;30.94,-13.44,;34.94,-14.21,;34.94,-15.76,;36.28,-16.52,;37.61,-15.75,;37.61,-14.2,;36.27,-13.44,)|
Show InChI InChI=1S/C27H25F3N4O3/c28-27(29,30)17-34(25(36)33-23-16-31-22(15-32-23)18-6-2-1-3-7-18)20-10-12-26(13-11-20)14-19-8-4-5-9-21(19)24(35)37-26/h1-9,15-16,20H,10-14,17H2,(H,32,33,36)/t20-,26+
KEGG

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Article
PubMed
 2.33E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranes

Bioorg Med Chem Lett 22: 2738-43 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.098
BindingDB Entry DOI: 10.7270/Q2154J34
More data for this
Ligand-Target Pair