null

SMILES: COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCCc2ccccc2)cc(OC)c1OC

InChI Key: InChIKey=JWEFMNVXBCOSGY-FQEVSTJZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50382667   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50382667 (CHEMBL2023549) Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCCc2ccccc2)cc(OC)c1OC |r| Show InChI InChI=1S/C27H33N5O4/c1-34-22-16-21(17-23(35-2)25(22)36-3)30-27-29-14-12-24(31-27)32-15-7-10-20(18-32)26(33)28-13-11-19-8-5-4-6-9-19/h4-6,8-9,12,14,16-17,20H,7,10-11,13,15,18H2,1-3H3,(H,28,33)(H,29,30,31)/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	358	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...				J Med Chem 55: 1698-705 (2012) Article DOI: 10.1021/jm201565s BindingDB Entry DOI: 10.7270/Q20P111R
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50382667 (CHEMBL2023549) Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCCc2ccccc2)cc(OC)c1OC |r| Show InChI InChI=1S/C27H33N5O4/c1-34-22-16-21(17-23(35-2)25(22)36-3)30-27-29-14-12-24(31-27)32-15-7-10-20(18-32)26(33)28-13-11-19-8-5-4-6-9-19/h4-6,8-9,12,14,16-17,20H,7,10-11,13,15,18H2,1-3H3,(H,28,33)(H,29,30,31)/t20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...				J Med Chem 55: 1698-705 (2012) Article DOI: 10.1021/jm201565s BindingDB Entry DOI: 10.7270/Q20P111R
					More data for this Ligand-Target Pair