null

SMILES: O=C(NCCc1ccccc1)Nc1ccc(cc1)-c1ccncc1

InChI Key: InChIKey=DXROFJODNNFSMZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50382693   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM50382693 (CHEMBL2023159 | US9409868, 25) Show SMILES O=C(NCCc1ccccc1)Nc1ccc(cc1)-c1ccncc1 Show InChI InChI=1S/C20H19N3O/c24-20(22-15-10-16-4-2-1-3-5-16)23-19-8-6-17(7-9-19)18-11-13-21-14-12-18/h1-9,11-14H,10,15H2,(H2,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	2.61E+3	n/a	n/a	n/a	n/a	7.5	25
H. Lee Moffin Cancer Center and Research Institute, Inc. US Patent					Assay Description A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...				US Patent US9409868 (2016) BindingDB Entry DOI: 10.7270/Q2X63KT0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50382693 (CHEMBL2023159 | US9409868, 25) Show SMILES O=C(NCCc1ccccc1)Nc1ccc(cc1)-c1ccncc1 Show InChI InChI=1S/C20H19N3O/c24-20(22-15-10-16-4-2-1-3-5-16)23-19-8-6-17(7-9-19)18-11-13-21-14-12-18/h1-9,11-14H,10,15H2,(H2,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
H. Lee Moffitt Cancer Center and Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assay				J Med Chem 55: 2474-8 (2012) Article DOI: 10.1021/jm201289r BindingDB Entry DOI: 10.7270/Q2MG7QH3
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50382693 (CHEMBL2023159 | US9409868, 25) Show SMILES O=C(NCCc1ccccc1)Nc1ccc(cc1)-c1ccncc1 Show InChI InChI=1S/C20H19N3O/c24-20(22-15-10-16-4-2-1-3-5-16)23-19-8-6-17(7-9-19)18-11-13-21-14-12-18/h1-9,11-14H,10,15H2,(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
H. Lee Moffitt Cancer Center and Research Institute Curated by ChEMBL					Assay Description Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assay				J Med Chem 55: 2474-8 (2012) Article DOI: 10.1021/jm201289r BindingDB Entry DOI: 10.7270/Q2MG7QH3
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM50382693 (CHEMBL2023159 | US9409868, 25) Show SMILES O=C(NCCc1ccccc1)Nc1ccc(cc1)-c1ccncc1 Show InChI InChI=1S/C20H19N3O/c24-20(22-15-10-16-4-2-1-3-5-16)23-19-8-6-17(7-9-19)18-11-13-21-14-12-18/h1-9,11-14H,10,15H2,(H2,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	1.98E+4	n/a	n/a	n/a	n/a	7.5	25
H. Lee Moffin Cancer Center and Research Institute, Inc. US Patent					Assay Description A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...				US Patent US9409868 (2016) BindingDB Entry DOI: 10.7270/Q2X63KT0
					More data for this Ligand-Target Pair