Compile Data Set for Download or QSAR

Found 260 hits Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 2 [1-552]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598601 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...) Show SMILES C1CC2CNCC1N2c1nc(Nc2ccc3[nH]ncc3c2)c2sccc2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598664 (Ethyl 2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluo...) Show SMILES CN(C)c1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598596 (2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...) Show SMILES C1C2CNCC1N2c1nc2COCc2c(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598630 (N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...) Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1C2CC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598602 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...) Show SMILES C1CC2CNCC1N2c1nc(Nc2ccc3[nH]ncc3c2)c2ccsc2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598581 (N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...) Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1CC2CC1CN2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598603 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...) Show SMILES C1CC2CNCC1N2c1nc2CCOCc2c(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598647 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluoro-...) Show SMILES COc1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578446 ((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chloropheny...) Show SMILES CN[C@@H](C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc(Cl)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598604 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...) Show SMILES C1CC2CNCC1N2c1nc2CNCc2c(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598655 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N4-ethyl-N6-...) Show SMILES CCN(C)c1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578479 ((S)—N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CN[C@H](C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1)c1cccc(OC)c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598584 (N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...) Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1C2CC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598562 (N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)pyrimidin...) Show SMILES C1C2CNCC1N2c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598666 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chloro-N4-...) Show SMILES CN(C)c1nc(nc(Nc2ccc3[nH]ncc3c2)c1Cl)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578424 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-chlorophenyl)-2...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(Cl)c1 |$;HN;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598652 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N4-(1H-indaz...) Show SMILES CNc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578438 ((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...) Show SMILES CNCCN[C@@H](C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578449 (3-(2-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-(methyla...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(c1)C(=O)NC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598631 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluoro-...) Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598606 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3,8-diazabicyclo[...) Show SMILES C1CC2CNCC1N2c1nc2CNCc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578470 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...) Show SMILES COc1cccc(c1)C(NCCN1CCOCC1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598636 (2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...) Show SMILES C1C2CNCC1N2c1nc2CCOCc2c(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578435 ((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...) Show SMILES COc1cccc(c1)[C@@H](NCCN(C)C)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578410 ((S)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...) Show SMILES CN[C@H](C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 |r,$;HN;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578409 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(2-methoxyphenyl)-...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccccc1OC |$;HN;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578454 (N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-pyra...) Show SMILES CNC(C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1)c1cccc(OC)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598517 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)pyrimidin-...) Show SMILES C1CC2CNCC1N2c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578415 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(ethylamino)-2-(p-...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc(C)cc1 |$;HN;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578420 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-chlorophenyl)-2...) Show SMILES CCNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(Cl)c1 |$;;HN;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598659 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N4-(1H-indaz...) Show SMILES CN(C)c1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598597 (N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro...) Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1CC2CC1CN2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598579 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluorop...) Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598639 (2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...) Show SMILES C1C2CNCC1N2c1nc2CNCc2c(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578411 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 |$;HN;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578415 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(ethylamino)-2-(p-...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc(C)cc1 |$;HN;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578423 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-fluorophenyl)-2...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc(F)cc1 |$;HN;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598594 (N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-chloro...) Show SMILES Clc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1C2CC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598586 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-methoxy...) Show SMILES COc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578430 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...) Show SMILES CNCCNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578476 (N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)-2-((2-meth...) Show SMILES COCCNC(C(=O)Nc1ccc(-c2cn[nH]c2)c(OC)c1)c1cccc(OC)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598665 (4-((1H-indazol-5-yl)amino)-2-(3,8-diazabicyclo[3.2...) Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C#N)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598663 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-6-(triflu...) Show SMILES FC(F)(F)c1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598577 (N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...) Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1C2CC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598654 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N4-(6-fluoro...) Show SMILES CN(C)c1cc(Nc2cc3cn[nH]c3cc2F)nc(n1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578421 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chlorophenyl)-2...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc(Cl)cc1 |$;HN;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578417 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(ethylamino)-2-(3-...) Show SMILES CCNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 |$;;HN;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578461 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...) Show SMILES CNCCCNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM598598 (2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...) Show SMILES C1CC2CNCC1N2c1nc2COCc2c(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human))	BDBM578418 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(methylamino)-2-(m...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(C)c1 |$;HN;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair

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