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SMILES: COc1cc(ccc1Nc1ncc2CN(C(C)C)C(=O)N(c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)CC1

InChI Key: InChIKey=RXRZLNAQLIRKLZ-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50383289   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50383289
PNG
(CHEMBL2029434)
Show SMILES COc1cc(ccc1Nc1ncc2CN(C(C)C)C(=O)N(c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C30H36N8O3/c1-6-27(39)32-22-8-7-9-24(16-22)38-28-21(19-37(20(2)3)30(38)40)18-31-29(34-28)33-25-11-10-23(17-26(25)41-5)36-14-12-35(4)13-15-36/h6-11,16-18,20H,1,12-15,19H2,2-5H3,(H,32,39)(H,31,33,34)
PDB
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KEGG

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antibodypedia
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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 0.380n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1.5 hr by FRET assay

J Med Chem 55: 2711-23 (2012)


Article DOI: 10.1021/jm201591k
BindingDB Entry DOI: 10.7270/Q2K938JM
More data for this
Ligand-Target Pair