Found 5 hits for monomerid = 50384542 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this Ligand-Target Pair | |