BDBM50385379 CHEMBL2036380

SMILES: CC(C)Cc1ccc(cc1)C(C)c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccccc1Cl

InChI Key: InChIKey=UGASTDYELDRSCE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50385379   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50385379 (CHEMBL2036380) Show SMILES CC(C)Cc1ccc(cc1)C(C)c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccccc1Cl Show InChI InChI=1S/C36H34ClN3O/c1-24(2)20-26-12-14-27(15-13-26)25(3)36-39-34-21-31(41-23-30-17-16-28-8-5-7-11-33(28)38-30)18-19-35(34)40(36)22-29-9-4-6-10-32(29)37/h4-19,21,24-25H,20,22-23H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins				Bioorg Med Chem 20: 3728-41 (2012) Article DOI: 10.1016/j.bmc.2012.04.048 BindingDB Entry DOI: 10.7270/Q26H4JFM
					More data for this Ligand-Target Pair