BDBM50385382 CHEMBL2036189

SMILES: COc1ccc(Cn2c(nc3ccccc23)C(C)c2ccc(CC(C)C)cc2)c(OC)c1OC

InChI Key: InChIKey=GJPXMMMPOSRWJK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50385382   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50385382 (CHEMBL2036189) Show SMILES COc1ccc(Cn2c(nc3ccccc23)C(C)c2ccc(CC(C)C)cc2)c(OC)c1OC Show InChI InChI=1S/C29H34N2O3/c1-19(2)17-21-11-13-22(14-12-21)20(3)29-30-24-9-7-8-10-25(24)31(29)18-23-15-16-26(32-4)28(34-6)27(23)33-5/h7-16,19-20H,17-18H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins				Bioorg Med Chem 20: 3728-41 (2012) Article DOI: 10.1016/j.bmc.2012.04.048 BindingDB Entry DOI: 10.7270/Q26H4JFM
					More data for this Ligand-Target Pair