BDBM50385384 CHEMBL2036157

SMILES: Cc1ccc(cc1)-n1c(SCC(=O)Nc2ccc(Cl)cc2C)nnc1-c1ccc(cc1)C(C)(C)C

InChI Key: InChIKey=XQAMJUCHQIYGOK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50385384   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50385384 (CHEMBL2036157) Show SMILES Cc1ccc(cc1)-n1c(SCC(=O)Nc2ccc(Cl)cc2C)nnc1-c1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C28H29ClN4OS/c1-18-6-13-23(14-7-18)33-26(20-8-10-21(11-9-20)28(3,4)5)31-32-27(33)35-17-25(34)30-24-15-12-22(29)16-19(24)2/h6-16H,17H2,1-5H3,(H,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins				Bioorg Med Chem 20: 3728-41 (2012) Article DOI: 10.1016/j.bmc.2012.04.048 BindingDB Entry DOI: 10.7270/Q26H4JFM
					More data for this Ligand-Target Pair