BDBM50385386 CHEMBL2036159

SMILES: CC(C)CNC(=O)CSc1nnc(-c2ccc(cc2)C(C)(C)C)n1-c1ccc(C)cc1

InChI Key: InChIKey=PUZKIKFWCUEOCE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50385386   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50385386 (CHEMBL2036159) Show SMILES CC(C)CNC(=O)CSc1nnc(-c2ccc(cc2)C(C)(C)C)n1-c1ccc(C)cc1 Show InChI InChI=1S/C25H32N4OS/c1-17(2)15-26-22(30)16-31-24-28-27-23(29(24)21-13-7-18(3)8-14-21)19-9-11-20(12-10-19)25(4,5)6/h7-14,17H,15-16H2,1-6H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins				Bioorg Med Chem 20: 3728-41 (2012) Article DOI: 10.1016/j.bmc.2012.04.048 BindingDB Entry DOI: 10.7270/Q26H4JFM
					More data for this Ligand-Target Pair