BDBM50385388 CHEMBL2036161

SMILES: COc1ccc(cc1OC)-c1c(C)[nH]nc1-c1ccc(OCc2c(Cl)cccc2Cl)cc1O

InChI Key: InChIKey=DZLUNIQMFXTNAG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50385388   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50385388 (CHEMBL2036161) Show SMILES COc1ccc(cc1OC)-c1c(C)[nH]nc1-c1ccc(OCc2c(Cl)cccc2Cl)cc1O Show InChI InChI=1S/C25H22Cl2N2O4/c1-14-24(15-7-10-22(31-2)23(11-15)32-3)25(29-28-14)17-9-8-16(12-21(17)30)33-13-18-19(26)5-4-6-20(18)27/h4-12,30H,13H2,1-3H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins				Bioorg Med Chem 20: 3728-41 (2012) Article DOI: 10.1016/j.bmc.2012.04.048 BindingDB Entry DOI: 10.7270/Q26H4JFM
					More data for this Ligand-Target Pair