BDBM50385391 CHEMBL2036164

SMILES: Cc1noc(c1-c1ccc(Cl)cc1)-c1ccc(OCc2ccccc2C)cc1O

InChI Key: InChIKey=OEYVIZBEEHPIEK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50385391   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50385391 (CHEMBL2036164) Show SMILES Cc1noc(c1-c1ccc(Cl)cc1)-c1ccc(OCc2ccccc2C)cc1O Show InChI InChI=1S/C24H20ClNO3/c1-15-5-3-4-6-18(15)14-28-20-11-12-21(22(27)13-20)24-23(16(2)26-29-24)17-7-9-19(25)10-8-17/h3-13,27H,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in Ca+2 ionophore A23187 stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 1...				Eur J Med Chem 113: 1-10 (2016) BindingDB Entry DOI: 10.7270/Q2BV7JHB
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50385391 (CHEMBL2036164) Show SMILES Cc1noc(c1-c1ccc(Cl)cc1)-c1ccc(OCc2ccccc2C)cc1O Show InChI InChI=1S/C24H20ClNO3/c1-15-5-3-4-6-18(15)14-28-20-11-12-21(22(27)13-20)24-23(16(2)26-29-24)17-7-9-19(25)10-8-17/h3-13,27H,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins				Bioorg Med Chem 20: 3728-41 (2012) Article DOI: 10.1016/j.bmc.2012.04.048 BindingDB Entry DOI: 10.7270/Q26H4JFM
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50385391 (CHEMBL2036164) Show SMILES Cc1noc(c1-c1ccc(Cl)cc1)-c1ccc(OCc2ccccc2C)cc1O Show InChI InChI=1S/C24H20ClNO3/c1-15-5-3-4-6-18(15)14-28-20-11-12-21(22(27)13-20)24-23(16(2)26-29-24)17-7-9-19(25)10-8-17/h3-13,27H,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 assessed as 5-LO product formation preincubated for 15 mins followed by addit...				Eur J Med Chem 113: 1-10 (2016) BindingDB Entry DOI: 10.7270/Q2BV7JHB
					More data for this Ligand-Target Pair