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SMILES: Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)CC4CC4)c3cc2C)c(C)c1

InChI Key: InChIKey=TZZRYYFXCFPPDN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50387020   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50387020
PNG
(CHEMBL2049194)
Show SMILES Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)CC4CC4)c3cc2C)c(C)c1
Show InChI InChI=1S/C27H33N3/c1-17-12-18(2)26(19(3)13-17)29-27-20(4)14-23-24(28-27)6-5-7-25(23)30(15-21-8-9-21)16-22-10-11-22/h5-7,12-14,21-22H,8-11,15-16H2,1-4H3,(H,28,29)
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n/an/a 75n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay

Bioorg Med Chem Lett 22: 4756-61 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW
More data for this
Ligand-Target Pair