BDBM50388535 CHEMBL2057225

SMILES: CC1(C)N(CCn2c(Nc3ccc(F)c(F)c3)c(nc12)-c1ccc(F)cc1)C(=O)CN

InChI Key: InChIKey=ROGAYXJGTZEBOA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50388535   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50388535 (CHEMBL2057225) Show SMILES CC1(C)N(CCn2c(Nc3ccc(F)c(F)c3)c(nc12)-c1ccc(F)cc1)C(=O)CN Show InChI InChI=1S/C22H22F3N5O/c1-22(2)21-28-19(13-3-5-14(23)6-4-13)20(27-15-7-8-16(24)17(25)11-15)29(21)9-10-30(22)18(31)12-26/h3-8,11,27H,9-10,12,26H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of human ERG channel expressed in CHO cells by patch clamp assay				J Med Chem 55: 4244-73 (2012) Article DOI: 10.1021/jm300041e BindingDB Entry DOI: 10.7270/Q21V5G1P
					More data for this Ligand-Target Pair