Found 6 hits for monomerid = 50389054 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389054
(CHEMBL2064411)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50389054
(CHEMBL2064411)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as ... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50389054
(CHEMBL2064411)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 373 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50389054
(CHEMBL2064411)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of mTOR |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50389054
(CHEMBL2064411)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389054
(CHEMBL2064411)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |