BDBM50389218 CHEMBL2063332

SMILES: Cc1cc(COC(=O)NCc2ccc(cc2)-c2cc(NC(=O)c3ccc(OCCN4CCCC4)cc3)[nH]n2)no1

InChI Key: InChIKey=JCKZGURUGPXEEO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50389218   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50389218 (CHEMBL2063332) Show SMILES Cc1cc(COC(=O)NCc2ccc(cc2)-c2cc(NC(=O)c3ccc(OCCN4CCCC4)cc3)[nH]n2)no1 Show InChI InChI=1S/C29H32N6O5/c1-20-16-24(34-40-20)19-39-29(37)30-18-21-4-6-22(7-5-21)26-17-27(33-32-26)31-28(36)23-8-10-25(11-9-23)38-15-14-35-12-2-3-13-35/h4-11,16-17H,2-3,12-15,18-19H2,1H3,(H,30,37)(H2,31,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 22: 4654-9 (2012) Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50389218 (CHEMBL2063332) Show SMILES Cc1cc(COC(=O)NCc2ccc(cc2)-c2cc(NC(=O)c3ccc(OCCN4CCCC4)cc3)[nH]n2)no1 Show InChI InChI=1S/C29H32N6O5/c1-20-16-24(34-40-20)19-39-29(37)30-18-21-4-6-22(7-5-21)26-17-27(33-32-26)31-28(36)23-8-10-25(11-9-23)38-15-14-35-12-2-3-13-35/h4-11,16-17H,2-3,12-15,18-19H2,1H3,(H,30,37)(H2,31,32,33,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of VEGFR1				Bioorg Med Chem Lett 22: 4654-9 (2012) Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50389218 (CHEMBL2063332) Show SMILES Cc1cc(COC(=O)NCc2ccc(cc2)-c2cc(NC(=O)c3ccc(OCCN4CCCC4)cc3)[nH]n2)no1 Show InChI InChI=1S/C29H32N6O5/c1-20-16-24(34-40-20)19-39-29(37)30-18-21-4-6-22(7-5-21)26-17-27(33-32-26)31-28(36)23-8-10-25(11-9-23)38-15-14-35-12-2-3-13-35/h4-11,16-17H,2-3,12-15,18-19H2,1H3,(H,30,37)(H2,31,32,33,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of wild type FLT3				Bioorg Med Chem Lett 22: 4654-9 (2012) Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50389218 (CHEMBL2063332) Show SMILES Cc1cc(COC(=O)NCc2ccc(cc2)-c2cc(NC(=O)c3ccc(OCCN4CCCC4)cc3)[nH]n2)no1 Show InChI InChI=1S/C29H32N6O5/c1-20-16-24(34-40-20)19-39-29(37)30-18-21-4-6-22(7-5-21)26-17-27(33-32-26)31-28(36)23-8-10-25(11-9-23)38-15-14-35-12-2-3-13-35/h4-11,16-17H,2-3,12-15,18-19H2,1H3,(H,30,37)(H2,31,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of Aurora A				Bioorg Med Chem Lett 22: 4654-9 (2012) Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV
					More data for this Ligand-Target Pair