Found 4 hits for monomerid = 50389225 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50389225
(CHEMBL2063434)Show SMILES Cc1nc(Nc2cc(n[nH]2)-c2ccc(CNC(=O)OCc3cccnc3)cc2)cc(n1)N1CCN(CCO)CC1 Show InChI InChI=1S/C28H33N9O3/c1-20-31-25(16-27(32-20)37-11-9-36(10-12-37)13-14-38)33-26-15-24(34-35-26)23-6-4-21(5-7-23)18-30-28(39)40-19-22-3-2-8-29-17-22/h2-8,15-17,38H,9-14,18-19H2,1H3,(H,30,39)(H2,31,32,33,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50389225
(CHEMBL2063434)Show SMILES Cc1nc(Nc2cc(n[nH]2)-c2ccc(CNC(=O)OCc3cccnc3)cc2)cc(n1)N1CCN(CCO)CC1 Show InChI InChI=1S/C28H33N9O3/c1-20-31-25(16-27(32-20)37-11-9-36(10-12-37)13-14-38)33-26-15-24(34-35-26)23-6-4-21(5-7-23)18-30-28(39)40-19-22-3-2-8-29-17-22/h2-8,15-17,38H,9-14,18-19H2,1H3,(H,30,39)(H2,31,32,33,34,35) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50389225
(CHEMBL2063434)Show SMILES Cc1nc(Nc2cc(n[nH]2)-c2ccc(CNC(=O)OCc3cccnc3)cc2)cc(n1)N1CCN(CCO)CC1 Show InChI InChI=1S/C28H33N9O3/c1-20-31-25(16-27(32-20)37-11-9-36(10-12-37)13-14-38)33-26-15-24(34-35-26)23-6-4-21(5-7-23)18-30-28(39)40-19-22-3-2-8-29-17-22/h2-8,15-17,38H,9-14,18-19H2,1H3,(H,30,39)(H2,31,32,33,34,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of wild type FLT3 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50389225
(CHEMBL2063434)Show SMILES Cc1nc(Nc2cc(n[nH]2)-c2ccc(CNC(=O)OCc3cccnc3)cc2)cc(n1)N1CCN(CCO)CC1 Show InChI InChI=1S/C28H33N9O3/c1-20-31-25(16-27(32-20)37-11-9-36(10-12-37)13-14-38)33-26-15-24(34-35-26)23-6-4-21(5-7-23)18-30-28(39)40-19-22-3-2-8-29-17-22/h2-8,15-17,38H,9-14,18-19H2,1H3,(H,30,39)(H2,31,32,33,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of Aurora A |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |