BDBM50389530 CHEMBL2063372

SMILES: CCN(CC)c1ccc(C)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC

InChI Key: InChIKey=UBNLUICXZOVIPA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50389530   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50389530 (CHEMBL2063372) Show SMILES CCN(CC)c1ccc(C)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(9.62,-11.23,;10.96,-12,;10.96,-13.54,;12.3,-14.3,;12.3,-15.84,;9.63,-14.31,;8.3,-13.55,;6.97,-14.32,;6.96,-15.86,;5.63,-16.63,;8.3,-16.63,;8.29,-18.17,;9.63,-18.94,;10.97,-18.17,;12.3,-18.93,;10.97,-16.63,;9.64,-15.86,;9.63,-20.48,;8.29,-21.25,;6.96,-20.48,;5.63,-21.25,;8.29,-22.79,;9.63,-23.56,;9.63,-25.1,;8.3,-25.87,;6.96,-25.1,;10.97,-22.78,;10.96,-21.24,;12.29,-20.47,;13.63,-21.24,)| Show InChI InChI=1S/C25H32N2O3/c1-8-27(9-2)20-11-10-16(3)24-19(20)12-17(4)25(26-24)23-21(29-6)13-18(15-28-5)14-22(23)30-7/h10-14H,8-9,15H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation after 3...				Bioorg Med Chem Lett 22: 5372-8 (2012) Article DOI: 10.1016/j.bmcl.2012.07.047 BindingDB Entry DOI: 10.7270/Q2736S12
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50389530 (CHEMBL2063372) Show SMILES CCN(CC)c1ccc(C)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(9.62,-11.23,;10.96,-12,;10.96,-13.54,;12.3,-14.3,;12.3,-15.84,;9.63,-14.31,;8.3,-13.55,;6.97,-14.32,;6.96,-15.86,;5.63,-16.63,;8.3,-16.63,;8.29,-18.17,;9.63,-18.94,;10.97,-18.17,;12.3,-18.93,;10.97,-16.63,;9.64,-15.86,;9.63,-20.48,;8.29,-21.25,;6.96,-20.48,;5.63,-21.25,;8.29,-22.79,;9.63,-23.56,;9.63,-25.1,;8.3,-25.87,;6.96,-25.1,;10.97,-22.78,;10.96,-21.24,;12.29,-20.47,;13.63,-21.24,)| Show InChI InChI=1S/C25H32N2O3/c1-8-27(9-2)20-11-10-16(3)24-19(20)12-17(4)25(26-24)23-21(29-6)13-18(15-28-5)14-22(23)30-7/h10-14H,8-9,15H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs				Bioorg Med Chem Lett 22: 5372-8 (2012) Article DOI: 10.1016/j.bmcl.2012.07.047 BindingDB Entry DOI: 10.7270/Q2736S12
					More data for this Ligand-Target Pair