BDBM50389537 CHEMBL2063380

SMILES: CCN(CC)c1ccc(C)c2nc(ccc12)-c1c(OC)cc(COC)cc1OC

InChI Key: InChIKey=JFHJTHQBLSHFIU-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50389537   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50389537 (CHEMBL2063380) Show SMILES CCN(CC)c1ccc(C)c2nc(ccc12)-c1c(OC)cc(COC)cc1OC Show InChI InChI=1S/C24H30N2O3/c1-7-26(8-2)20-12-9-16(3)24-18(20)10-11-19(25-24)23-21(28-5)13-17(15-27-4)14-22(23)29-6/h9-14H,7-8,15H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	381	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50389537 (CHEMBL2063380) Show SMILES CCN(CC)c1ccc(C)c2nc(ccc12)-c1c(OC)cc(COC)cc1OC Show InChI InChI=1S/C24H30N2O3/c1-7-26(8-2)20-12-9-16(3)24-18(20)10-11-19(25-24)23-21(28-5)13-17(15-27-4)14-22(23)29-6/h9-14H,7-8,15H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	381	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation after 3...				Bioorg Med Chem Lett 22: 5372-8 (2012) Article DOI: 10.1016/j.bmcl.2012.07.047 BindingDB Entry DOI: 10.7270/Q2736S12
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50389537 (CHEMBL2063380) Show SMILES CCN(CC)c1ccc(C)c2nc(ccc12)-c1c(OC)cc(COC)cc1OC Show InChI InChI=1S/C24H30N2O3/c1-7-26(8-2)20-12-9-16(3)24-18(20)10-11-19(25-24)23-21(28-5)13-17(15-27-4)14-22(23)29-6/h9-14H,7-8,15H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs				Bioorg Med Chem Lett 22: 5372-8 (2012) Article DOI: 10.1016/j.bmcl.2012.07.047 BindingDB Entry DOI: 10.7270/Q2736S12
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50389537 (CHEMBL2063380) Show SMILES CCN(CC)c1ccc(C)c2nc(ccc12)-c1c(OC)cc(COC)cc1OC Show InChI InChI=1S/C24H30N2O3/c1-7-26(8-2)20-12-9-16(3)24-18(20)10-11-19(25-24)23-21(28-5)13-17(15-27-4)14-22(23)29-6/h9-14H,7-8,15H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation counting				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair