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SMILES: C[C@@H](N1C[C@@H](CC1=O)c1nc(no1)-c1cccc(Cl)c1)c1ccccc1

InChI Key: InChIKey=KLDWQBZKNJLAAM-CZUORRHYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390068   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50390068
PNG
(CHEMBL2069388)
Show SMILES C[C@@H](N1C[C@@H](CC1=O)c1nc(no1)-c1cccc(Cl)c1)c1ccccc1 |r|
Show InChI InChI=1S/C20H18ClN3O2/c1-13(14-6-3-2-4-7-14)24-12-16(11-18(24)25)20-22-19(23-26-20)15-8-5-9-17(21)10-15/h2-10,13,16H,11-12H2,1H3/t13-,16-/m1/s1
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MMDB

KEGG

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Similars
Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium flux by FLIPR method

Bioorg Med Chem Lett 22: 5658-62 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.094
BindingDB Entry DOI: 10.7270/Q2348MF7
More data for this
Ligand-Target Pair