Found 5 hits for monomerid = 50390406 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cathepsin B
(Homo sapiens (Human)) | BDBM50390406
(CHEMBL2069324)Show SMILES O=C(NC1(CC1)C#N)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1nc(cs1)-c1ccccc1 |r| Show InChI InChI=1S/C25H29N5O2S/c26-17-25(10-11-25)28-22(31)19-8-4-5-9-20(19)23(32)29-12-14-30(15-13-29)24-27-21(16-33-24)18-6-2-1-3-7-18/h1-3,6-7,16,19-20H,4-5,8-15H2,(H,28,31)/t19-,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cathepsin B using Z-Arg-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent res... |
Bioorg Med Chem Lett 22: 5563-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.012 BindingDB Entry DOI: 10.7270/Q2DF6S86 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50390406
(CHEMBL2069324)Show SMILES O=C(NC1(CC1)C#N)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1nc(cs1)-c1ccccc1 |r| Show InChI InChI=1S/C25H29N5O2S/c26-17-25(10-11-25)28-22(31)19-8-4-5-9-20(19)23(32)29-12-14-30(15-13-29)24-27-21(16-33-24)18-6-2-1-3-7-18/h1-3,6-7,16,19-20H,4-5,8-15H2,(H,28,31)/t19-,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
Bioorg Med Chem Lett 22: 5563-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.012 BindingDB Entry DOI: 10.7270/Q2DF6S86 |
More data for this Ligand-Target Pair | |
Cathepsin S
(Homo sapiens (Human)) | BDBM50390406
(CHEMBL2069324)Show SMILES O=C(NC1(CC1)C#N)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1nc(cs1)-c1ccccc1 |r| Show InChI InChI=1S/C25H29N5O2S/c26-17-25(10-11-25)28-22(31)19-8-4-5-9-20(19)23(32)29-12-14-30(15-13-29)24-27-21(16-33-24)18-6-2-1-3-7-18/h1-3,6-7,16,19-20H,4-5,8-15H2,(H,28,31)/t19-,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cathepsin S using Z-Val-Val-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent... |
Bioorg Med Chem Lett 22: 5563-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.012 BindingDB Entry DOI: 10.7270/Q2DF6S86 |
More data for this Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50390406
(CHEMBL2069324)Show SMILES O=C(NC1(CC1)C#N)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1nc(cs1)-c1ccccc1 |r| Show InChI InChI=1S/C25H29N5O2S/c26-17-25(10-11-25)28-22(31)19-8-4-5-9-20(19)23(32)29-12-14-30(15-13-29)24-27-21(16-33-24)18-6-2-1-3-7-18/h1-3,6-7,16,19-20H,4-5,8-15H2,(H,28,31)/t19-,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cathepsin L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent res... |
Bioorg Med Chem Lett 22: 5563-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.012 BindingDB Entry DOI: 10.7270/Q2DF6S86 |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50390406
(CHEMBL2069324)Show SMILES O=C(NC1(CC1)C#N)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1nc(cs1)-c1ccccc1 |r| Show InChI InChI=1S/C25H29N5O2S/c26-17-25(10-11-25)28-22(31)19-8-4-5-9-20(19)23(32)29-12-14-30(15-13-29)24-27-21(16-33-24)18-6-2-1-3-7-18/h1-3,6-7,16,19-20H,4-5,8-15H2,(H,28,31)/t19-,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 15.8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cathepsin K using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent res... |
Bioorg Med Chem Lett 22: 5563-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.012 BindingDB Entry DOI: 10.7270/Q2DF6S86 |
More data for this Ligand-Target Pair | |