BDBM50390496 CHEMBL2071610

SMILES: Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1

InChI Key: InChIKey=VFAPMHXLINRCAL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50390496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform alpha (Homo sapiens (Human))	BDBM50390496 (CHEMBL2071610) Show SMILES Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C19H12FN5/c20-18-15(2-1-9-22-18)13-4-6-14(7-5-13)23-19-24-16-8-3-12(11-21)10-17(16)25-19/h1-10H,(H2,23,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CK1alpha by Lance assay				Bioorg Med Chem Lett 22: 5392-5 (2012) Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q
					More data for this Ligand-Target Pair
Casein kinase I (Homo sapiens (Human))	BDBM50390496 (CHEMBL2071610) Show SMILES Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C19H12FN5/c20-18-15(2-1-9-22-18)13-4-6-14(7-5-13)23-19-24-16-8-3-12(11-21)10-17(16)25-19/h1-10H,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting				Bioorg Med Chem Lett 22: 5392-5 (2012) Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50390496 (CHEMBL2071610) Show SMILES Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C19H12FN5/c20-18-15(2-1-9-22-18)13-4-6-14(7-5-13)23-19-24-16-8-3-12(11-21)10-17(16)25-19/h1-10H,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of GSK3beta by AlphaScreen assay				Bioorg Med Chem Lett 22: 5392-5 (2012) Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q
					More data for this Ligand-Target Pair
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM50390496 (CHEMBL2071610) Show SMILES Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C19H12FN5/c20-18-15(2-1-9-22-18)13-4-6-14(7-5-13)23-19-24-16-8-3-12(11-21)10-17(16)25-19/h1-10H,(H2,23,24,25)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CK1delta by Lance assay				Bioorg Med Chem Lett 22: 5392-5 (2012) Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q
					More data for this Ligand-Target Pair