BindingDB logo
myBDB logout

BDBM50390899 CHEMBL2070993

SMILES: COc1ccc(cc1)-c1csc(NC(=O)[C@H](NS(=O)(=O)c2ccc(C)cc2)C(C)(C)C)n1

InChI Key: InChIKey=UANFYVVHKDEOGE-FQEVSTJZSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390899   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390899
PNG
(CHEMBL2070993)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H](NS(=O)(=O)c2ccc(C)cc2)C(C)(C)C)n1 |r|
Show InChI InChI=1S/C23H27N3O4S2/c1-15-6-12-18(13-7-15)32(28,29)26-20(23(2,3)4)21(27)25-22-24-19(14-31-22)16-8-10-17(30-5)11-9-16/h6-14,20,26H,1-5H3,(H,24,25,27)/t20-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair