BDBM50391899 CHEMBL2147539

SMILES: NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1

InChI Key: InChIKey=UNULBQHMZBESJQ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50391899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C, eta (Homo sapiens (Human))	BDBM50391899 (CHEMBL2147539) Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1 Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	452	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...				Bioorg Med Chem Lett 21: 7367-72 (2011) Article DOI: 10.1016/j.bmcl.2011.10.025 BindingDB Entry DOI: 10.7270/Q22J6CZ4
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50391899 (CHEMBL2147539) Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1 Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	818	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...				Bioorg Med Chem Lett 21: 7367-72 (2011) Article DOI: 10.1016/j.bmcl.2011.10.025 BindingDB Entry DOI: 10.7270/Q22J6CZ4
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50391899 (CHEMBL2147539) Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1 Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...				Bioorg Med Chem Lett 21: 7367-72 (2011) Article DOI: 10.1016/j.bmcl.2011.10.025 BindingDB Entry DOI: 10.7270/Q22J6CZ4
					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50391899 (CHEMBL2147539) Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1 Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	932	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...				Bioorg Med Chem Lett 21: 7367-72 (2011) Article DOI: 10.1016/j.bmcl.2011.10.025 BindingDB Entry DOI: 10.7270/Q22J6CZ4
					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50391899 (CHEMBL2147539) Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1 Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	403	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...				Bioorg Med Chem Lett 21: 7367-72 (2011) Article DOI: 10.1016/j.bmcl.2011.10.025 BindingDB Entry DOI: 10.7270/Q22J6CZ4
					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50391899 (CHEMBL2147539) Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1 Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...				Bioorg Med Chem Lett 21: 7367-72 (2011) Article DOI: 10.1016/j.bmcl.2011.10.025 BindingDB Entry DOI: 10.7270/Q22J6CZ4
					More data for this Ligand-Target Pair