Found 4 hits for monomerid = 50391997 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50391997
(CHEMBL2152301)Show SMILES C(N1CCC[C@H](C1)n1cnc2cnc3[nH]ccc3c12)c1ccccc1 |r| Show InChI InChI=1S/C20H21N5/c1-2-5-15(6-3-1)12-24-10-4-7-16(13-24)25-14-23-18-11-22-20-17(19(18)25)8-9-21-20/h1-3,5-6,8-9,11,14,16H,4,7,10,12-13H2,(H,21,22)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of JAK1 |
J Med Chem 55: 5901-21 (2012)
Article DOI: 10.1021/jm300438j
BindingDB Entry DOI: 10.7270/Q2DV1KZX |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50391997
(CHEMBL2152301)Show SMILES C(N1CCC[C@H](C1)n1cnc2cnc3[nH]ccc3c12)c1ccccc1 |r| Show InChI InChI=1S/C20H21N5/c1-2-5-15(6-3-1)12-24-10-4-7-16(13-24)25-14-23-18-11-22-20-17(19(18)25)8-9-21-20/h1-3,5-6,8-9,11,14,16H,4,7,10,12-13H2,(H,21,22)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of JAK2 |
J Med Chem 55: 5901-21 (2012)
Article DOI: 10.1021/jm300438j
BindingDB Entry DOI: 10.7270/Q2DV1KZX |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50391997
(CHEMBL2152301)Show SMILES C(N1CCC[C@H](C1)n1cnc2cnc3[nH]ccc3c12)c1ccccc1 |r| Show InChI InChI=1S/C20H21N5/c1-2-5-15(6-3-1)12-24-10-4-7-16(13-24)25-14-23-18-11-22-20-17(19(18)25)8-9-21-20/h1-3,5-6,8-9,11,14,16H,4,7,10,12-13H2,(H,21,22)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of JAK3 |
J Med Chem 55: 5901-21 (2012)
Article DOI: 10.1021/jm300438j
BindingDB Entry DOI: 10.7270/Q2DV1KZX |
More data for this
Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50391997
(CHEMBL2152301)Show SMILES C(N1CCC[C@H](C1)n1cnc2cnc3[nH]ccc3c12)c1ccccc1 |r| Show InChI InChI=1S/C20H21N5/c1-2-5-15(6-3-1)12-24-10-4-7-16(13-24)25-14-23-18-11-22-20-17(19(18)25)8-9-21-20/h1-3,5-6,8-9,11,14,16H,4,7,10,12-13H2,(H,21,22)/t16-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of TYK2 |
J Med Chem 55: 5901-21 (2012)
Article DOI: 10.1021/jm300438j
BindingDB Entry DOI: 10.7270/Q2DV1KZX |
More data for this
Ligand-Target Pair | |
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