BDBM50392227 CHEMBL2153183

SMILES: CCCSc1nc(N[C@H]2CC[C@@H](CC2)C(O)=O)ccc1C(=O)NC1CCCCC1

InChI Key: InChIKey=LSNUPHZZOYTURX-JCNLHEQBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50392227   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50392227 (CHEMBL2153183) Show SMILES CCCSc1nc(N[C@H]2CC[C@@H](CC2)C(O)=O)ccc1C(=O)NC1CCCCC1 |r,wU:11.14,wD:8.7,(37.74,-32.28,;36.41,-33.05,;35.07,-32.28,;35.07,-30.74,;33.74,-29.98,;32.4,-30.75,;31.06,-29.98,;29.74,-30.74,;28.4,-29.97,;28.41,-28.43,;27.09,-27.66,;25.75,-28.43,;25.74,-29.97,;27.08,-30.75,;24.41,-27.65,;24.42,-26.11,;23.08,-28.41,;31.07,-28.43,;32.4,-27.66,;33.73,-28.43,;35.06,-27.65,;35.06,-26.11,;36.4,-28.42,;37.73,-27.64,;39.07,-28.42,;40.4,-27.65,;40.4,-26.11,;39.06,-25.34,;37.72,-26.11,)| Show InChI InChI=1S/C22H33N3O3S/c1-2-14-29-21-18(20(26)24-16-6-4-3-5-7-16)12-13-19(25-21)23-17-10-8-15(9-11-17)22(27)28/h12-13,15-17H,2-11,14H2,1H3,(H,23,25)(H,24,26)(H,27,28)/t15-,17-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged full length human 11betaHSD1 expressed in baculovirus infected cells using cortisone as substrate after 25 mins ...				J Med Chem 55: 5951-64 (2012) Article DOI: 10.1021/jm300592r BindingDB Entry DOI: 10.7270/Q24F1RTK
					More data for this Ligand-Target Pair