null

SMILES: CNC(=O)c1nc(cnc1N)-c1ccc(OC)c(c1)S(=O)(=O)Nc1ccccc1

InChI Key: InChIKey=FBXSSTFHXMDNAW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50393343   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50393343 (CHEMBL2152134) Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(OC)c(c1)S(=O)(=O)Nc1ccccc1 Show InChI InChI=1S/C19H19N5O4S/c1-21-19(25)17-18(20)22-11-14(23-17)12-8-9-15(28-2)16(10-12)29(26,27)24-13-6-4-3-5-7-13/h3-11,24H,1-2H3,(H2,20,22)(H,21,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	507	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assay				J Med Chem 55: 5467-82 (2012) Article DOI: 10.1021/jm300403a BindingDB Entry DOI: 10.7270/Q2DF6S9N
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50393343 (CHEMBL2152134) Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(OC)c(c1)S(=O)(=O)Nc1ccccc1 Show InChI InChI=1S/C19H19N5O4S/c1-21-19(25)17-18(20)22-11-14(23-17)12-8-9-15(28-2)16(10-12)29(26,27)24-13-6-4-3-5-7-13/h3-11,24H,1-2H3,(H2,20,22)(H,21,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of human PI3Kdelta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...				J Med Chem 55: 5467-82 (2012) Article DOI: 10.1021/jm300403a BindingDB Entry DOI: 10.7270/Q2DF6S9N
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50393343 (CHEMBL2152134) Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(OC)c(c1)S(=O)(=O)Nc1ccccc1 Show InChI InChI=1S/C19H19N5O4S/c1-21-19(25)17-18(20)22-11-14(23-17)12-8-9-15(28-2)16(10-12)29(26,27)24-13-6-4-3-5-7-13/h3-11,24H,1-2H3,(H2,20,22)(H,21,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of human PI3Kbeta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescenc...				J Med Chem 55: 5467-82 (2012) Article DOI: 10.1021/jm300403a BindingDB Entry DOI: 10.7270/Q2DF6S9N
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50393343 (CHEMBL2152134) Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(OC)c(c1)S(=O)(=O)Nc1ccccc1 Show InChI InChI=1S/C19H19N5O4S/c1-21-19(25)17-18(20)22-11-14(23-17)12-8-9-15(28-2)16(10-12)29(26,27)24-13-6-4-3-5-7-13/h3-11,24H,1-2H3,(H2,20,22)(H,21,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of human PI3Kalpha expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...				J Med Chem 55: 5467-82 (2012) Article DOI: 10.1021/jm300403a BindingDB Entry DOI: 10.7270/Q2DF6S9N
					More data for this Ligand-Target Pair