BDBM50393542 CHEMBL2158228

SMILES: NC(=O)CN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1

InChI Key: InChIKey=WFLCXRISIXFCBZ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50393542   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50393542 (CHEMBL2158228) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:29| Show InChI InChI=1S/C24H28N6O2/c25-13-19-14-27-23(28-19)24(32)29-21-7-6-18(12-20(21)17-4-2-1-3-5-17)16-8-10-30(11-9-16)15-22(26)31/h4,6-7,12,14,16H,1-3,5,8-11,15H2,(H2,26,31)(H,27,28)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse))	BDBM50393542 (CHEMBL2158228) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:29| Show InChI InChI=1S/C24H28N6O2/c25-13-19-14-27-23(28-19)24(32)29-21-7-6-18(12-20(21)17-4-2-1-3-5-17)16-8-10-30(11-9-16)15-22(26)31/h4,6-7,12,14,16H,1-3,5,8-11,15H2,(H2,26,31)(H,27,28)(H,29,32)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50393542 (CHEMBL2158228) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:29| Show InChI InChI=1S/C24H28N6O2/c25-13-19-14-27-23(28-19)24(32)29-21-7-6-18(12-20(21)17-4-2-1-3-5-17)16-8-10-30(11-9-16)15-22(26)31/h4,6-7,12,14,16H,1-3,5,8-11,15H2,(H2,26,31)(H,27,28)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50393542 (CHEMBL2158228) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:29| Show InChI InChI=1S/C24H28N6O2/c25-13-19-14-27-23(28-19)24(32)29-21-7-6-18(12-20(21)17-4-2-1-3-5-17)16-8-10-30(11-9-16)15-22(26)31/h4,6-7,12,14,16H,1-3,5,8-11,15H2,(H2,26,31)(H,27,28)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of CYP2C9				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50393542 (CHEMBL2158228) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:29| Show InChI InChI=1S/C24H28N6O2/c25-13-19-14-27-23(28-19)24(32)29-21-7-6-18(12-20(21)17-4-2-1-3-5-17)16-8-10-30(11-9-16)15-22(26)31/h4,6-7,12,14,16H,1-3,5,8-11,15H2,(H2,26,31)(H,27,28)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of CYP2C19				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Cytochrome P450 1A (Homo sapiens (Human))	BDBM50393542 (CHEMBL2158228) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:29| Show InChI InChI=1S/C24H28N6O2/c25-13-19-14-27-23(28-19)24(32)29-21-7-6-18(12-20(21)17-4-2-1-3-5-17)16-8-10-30(11-9-16)15-22(26)31/h4,6-7,12,14,16H,1-3,5,8-11,15H2,(H2,26,31)(H,27,28)(H,29,32)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of CYP1A2				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair