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SMILES: Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CCCNC1

InChI Key: InChIKey=JLXMMTXJUXILOC-JTQLQIEISA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50393759   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50393759 (CHEMBL2159201) Show SMILES Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CCCNC1 |r| Show InChI InChI=1S/C14H17N5/c1-9-18-12-8-17-14-11(4-6-16-14)13(12)19(9)10-3-2-5-15-7-10/h4,6,8,10,15H,2-3,5,7H2,1H3,(H,16,17)/t10-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...				J Med Chem 55: 6176-93 (2012) Article DOI: 10.1021/jm300628c BindingDB Entry DOI: 10.7270/Q25Q4X6S
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50393759 (CHEMBL2159201) Show SMILES Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CCCNC1 |r| Show InChI InChI=1S/C14H17N5/c1-9-18-12-8-17-14-11(4-6-16-14)13(12)19(9)10-3-2-5-15-7-10/h4,6,8,10,15H,2-3,5,7H2,1H3,(H,16,17)/t10-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	580	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...				J Med Chem 55: 6176-93 (2012) Article DOI: 10.1021/jm300628c BindingDB Entry DOI: 10.7270/Q25Q4X6S
					More data for this Ligand-Target Pair