null

SMILES: COCCN(CC(C)C)c1ccc(OC)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC

InChI Key: InChIKey=HAWIDCANNJBIHK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394517   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394517 (CHEMBL2160173) Show SMILES COCCN(CC(C)C)c1ccc(OC)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(1.41,9.22,;.07,8.47,;.05,6.93,;1.37,6.14,;1.35,4.6,;2.68,3.82,;4.02,4.57,;5.34,3.78,;4.04,6.11,;.01,3.85,;-1.31,4.64,;-2.66,3.88,;-2.68,2.34,;-4.02,1.59,;-5.34,2.38,;-1.35,1.56,;-1.37,.02,;-.05,-.77,;1.29,-.02,;2.62,-.8,;1.31,1.52,;-.01,2.31,;-.07,-2.31,;-1.41,-3.06,;-2.74,-2.28,;-4.08,-3.03,;-1.43,-4.6,;-.11,-5.39,;-.13,-6.93,;-1.47,-7.68,;-1.49,-9.22,;1.24,-4.64,;1.25,-3.1,;2.6,-2.34,;3.92,-3.13,)| Show InChI InChI=1S/C28H38N2O5/c1-18(2)16-30(11-12-31-4)22-9-10-23(33-6)28-21(22)13-19(3)27(29-28)26-24(34-7)14-20(17-32-5)15-25(26)35-8/h9-10,13-15,18H,11-12,16-17H2,1-8H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation counting				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394517 (CHEMBL2160173) Show SMILES COCCN(CC(C)C)c1ccc(OC)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(1.41,9.22,;.07,8.47,;.05,6.93,;1.37,6.14,;1.35,4.6,;2.68,3.82,;4.02,4.57,;5.34,3.78,;4.04,6.11,;.01,3.85,;-1.31,4.64,;-2.66,3.88,;-2.68,2.34,;-4.02,1.59,;-5.34,2.38,;-1.35,1.56,;-1.37,.02,;-.05,-.77,;1.29,-.02,;2.62,-.8,;1.31,1.52,;-.01,2.31,;-.07,-2.31,;-1.41,-3.06,;-2.74,-2.28,;-4.08,-3.03,;-1.43,-4.6,;-.11,-5.39,;-.13,-6.93,;-1.47,-7.68,;-1.49,-9.22,;1.24,-4.64,;1.25,-3.1,;2.6,-2.34,;3.92,-3.13,)| Show InChI InChI=1S/C28H38N2O5/c1-18(2)16-30(11-12-31-4)22-9-10-23(33-6)28-21(22)13-19(3)27(29-28)26-24(34-7)14-20(17-32-5)15-25(26)35-8/h9-10,13-15,18H,11-12,16-17H2,1-8H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair