null

SMILES: CCN(CC)c1ccc(OC)c2nc(c(F)cc12)-c1c(OC)cc(COC)cc1OC

InChI Key: InChIKey=RATJKEGVDDQIEC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394522   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394522 (CHEMBL2160168) Show SMILES CCN(CC)c1ccc(OC)c2nc(c(F)cc12)-c1c(OC)cc(COC)cc1OC |(3.29,8.1,;1.96,7.32,;1.97,5.78,;3.31,5.02,;4.64,5.79,;.64,5,;-.7,5.76,;-2.03,4.98,;-2.02,3.44,;-3.35,2.67,;-4.69,3.43,;-.68,2.68,;-.67,1.14,;.67,.38,;2,1.16,;3.34,.4,;1.99,2.7,;.65,3.46,;.68,-1.16,;-.65,-1.94,;-1.99,-1.18,;-3.32,-1.95,;-.64,-3.48,;.7,-4.24,;.71,-5.78,;-.62,-6.56,;-.61,-8.1,;2.03,-3.46,;2.02,-1.92,;3.35,-1.14,;4.69,-1.9,)| Show InChI InChI=1S/C24H29FN2O4/c1-7-27(8-2)18-9-10-19(29-4)23-16(18)13-17(25)24(26-23)22-20(30-5)11-15(14-28-3)12-21(22)31-6/h9-13H,7-8,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation counting				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394522 (CHEMBL2160168) Show SMILES CCN(CC)c1ccc(OC)c2nc(c(F)cc12)-c1c(OC)cc(COC)cc1OC |(3.29,8.1,;1.96,7.32,;1.97,5.78,;3.31,5.02,;4.64,5.79,;.64,5,;-.7,5.76,;-2.03,4.98,;-2.02,3.44,;-3.35,2.67,;-4.69,3.43,;-.68,2.68,;-.67,1.14,;.67,.38,;2,1.16,;3.34,.4,;1.99,2.7,;.65,3.46,;.68,-1.16,;-.65,-1.94,;-1.99,-1.18,;-3.32,-1.95,;-.64,-3.48,;.7,-4.24,;.71,-5.78,;-.62,-6.56,;-.61,-8.1,;2.03,-3.46,;2.02,-1.92,;3.35,-1.14,;4.69,-1.9,)| Show InChI InChI=1S/C24H29FN2O4/c1-7-27(8-2)18-9-10-19(29-4)23-16(18)13-17(25)24(26-23)22-20(30-5)11-15(14-28-3)12-21(22)31-6/h9-13H,7-8,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair