BDBM50394683 CHEMBL2165616

SMILES: CN(C)C(=O)c1cnc(Oc2cc(cc3oc(C)cc23)C(=O)Nc2cnc(C)cn2)cn1

InChI Key: InChIKey=DWVPDUMIGCPRPB-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394683   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucokinase/Glucokinase regulatory protein (Homo sapiens (Human))	BDBM50394683 (CHEMBL2165616) Show SMILES CN(C)C(=O)c1cnc(Oc2cc(cc3oc(C)cc23)C(=O)Nc2cnc(C)cn2)cn1 Show InChI InChI=1S/C22H20N6O4/c1-12-8-25-19(10-23-12)27-21(29)14-6-17-15(5-13(2)31-17)18(7-14)32-20-11-24-16(9-26-20)22(30)28(3)4/h5-11H,1-4H3,(H,25,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Activation of recombinant human glucokinase assessed measuring rate of glucose 6-phosphate formation using G6PDH/NADP coupling				Bioorg Med Chem Lett 22: 7100-5 (2012) Article DOI: 10.1016/j.bmcl.2012.09.082 BindingDB Entry DOI: 10.7270/Q2GM88H7
					More data for this Ligand-Target Pair
Glucokinase/Glucokinase regulatory protein (Homo sapiens (Human))	BDBM50394683 (CHEMBL2165616) Show SMILES CN(C)C(=O)c1cnc(Oc2cc(cc3oc(C)cc23)C(=O)Nc2cnc(C)cn2)cn1 Show InChI InChI=1S/C22H20N6O4/c1-12-8-25-19(10-23-12)27-21(29)14-6-17-15(5-13(2)31-17)18(7-14)32-20-11-24-16(9-26-20)22(30)28(3)4/h5-11H,1-4H3,(H,25,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	212	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysis				J Med Chem 55: 1318-33 (2012) Article DOI: 10.1021/jm2014887 BindingDB Entry DOI: 10.7270/Q2NG4RRT
					More data for this Ligand-Target Pair