Found 7 hits for monomerid = 50394841 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50394841
(CHEMBL2165004 | US8772480, 228)Show SMILES COc1ccc(Nc2ncc(CN3CCC(C3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C21H26N8O3S/c1-13-25-20(28-21(22)26-13)17-8-14(11-29-7-6-16(12-29)33(3,30)31)9-24-19(17)27-15-4-5-18(32-2)23-10-15/h4-5,8-10,16H,6-7,11-12H2,1-3H3,(H,24,27)(H2,22,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50394841
(CHEMBL2165004 | US8772480, 228)Show SMILES COc1ccc(Nc2ncc(CN3CCC(C3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C21H26N8O3S/c1-13-25-20(28-21(22)26-13)17-8-14(11-29-7-6-16(12-29)33(3,30)31)9-24-19(17)27-15-4-5-18(32-2)23-10-15/h4-5,8-10,16H,6-7,11-12H2,1-3H3,(H,24,27)(H2,22,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50394841
(CHEMBL2165004 | US8772480, 228)Show SMILES COc1ccc(Nc2ncc(CN3CCC(C3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C21H26N8O3S/c1-13-25-20(28-21(22)26-13)17-8-14(11-29-7-6-16(12-29)33(3,30)31)9-24-19(17)27-15-4-5-18(32-2)23-10-15/h4-5,8-10,16H,6-7,11-12H2,1-3H3,(H,24,27)(H2,22,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50394841
(CHEMBL2165004 | US8772480, 228)Show SMILES COc1ccc(Nc2ncc(CN3CCC(C3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C21H26N8O3S/c1-13-25-20(28-21(22)26-13)17-8-14(11-29-7-6-16(12-29)33(3,30)31)9-24-19(17)27-15-4-5-18(32-2)23-10-15/h4-5,8-10,16H,6-7,11-12H2,1-3H3,(H,24,27)(H2,22,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI... |
US Patent US8772480 (2014)
BindingDB Entry DOI: 10.7270/Q2V123FJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50394841
(CHEMBL2165004 | US8772480, 228)Show SMILES COc1ccc(Nc2ncc(CN3CCC(C3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C21H26N8O3S/c1-13-25-20(28-21(22)26-13)17-8-14(11-29-7-6-16(12-29)33(3,30)31)9-24-19(17)27-15-4-5-18(32-2)23-10-15/h4-5,8-10,16H,6-7,11-12H2,1-3H3,(H,24,27)(H2,22,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50394841
(CHEMBL2165004 | US8772480, 228)Show SMILES COc1ccc(Nc2ncc(CN3CCC(C3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C21H26N8O3S/c1-13-25-20(28-21(22)26-13)17-8-14(11-29-7-6-16(12-29)33(3,30)31)9-24-19(17)27-15-4-5-18(32-2)23-10-15/h4-5,8-10,16H,6-7,11-12H2,1-3H3,(H,24,27)(H2,22,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50394841
(CHEMBL2165004 | US8772480, 228)Show SMILES COc1ccc(Nc2ncc(CN3CCC(C3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C21H26N8O3S/c1-13-25-20(28-21(22)26-13)17-8-14(11-29-7-6-16(12-29)33(3,30)31)9-24-19(17)27-15-4-5-18(32-2)23-10-15/h4-5,8-10,16H,6-7,11-12H2,1-3H3,(H,24,27)(H2,22,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit... |
US Patent US8772480 (2014)
BindingDB Entry DOI: 10.7270/Q2V123FJ |
More data for this Ligand-Target Pair | |