null

SMILES: CN(C)C1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-n2cnc3ccccc23)CC1

InChI Key: InChIKey=ZOSVUXYDRZPQIL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394898   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50394898 (CHEMBL2165497) Show SMILES CN(C)C1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-n2cnc3ccccc23)CC1 Show InChI InChI=1S/C25H31N7OS/c1-29(2)18-7-9-30(10-8-18)16-19-15-21-23(34-19)24(31-11-13-33-14-12-31)28-25(27-21)32-17-26-20-5-3-4-6-22(20)32/h3-6,15,17-18H,7-14,16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human PI3Kdelta-mediated AKT phosphorylation at S473 in Ri-1 cells after 30 mins by electrochemiluminescence assay in presence of human...				J Med Chem 55: 5887-900 (2012) Article DOI: 10.1021/jm3003747 BindingDB Entry DOI: 10.7270/Q2V125XN
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50394898 (CHEMBL2165497) Show SMILES CN(C)C1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-n2cnc3ccccc23)CC1 Show InChI InChI=1S/C25H31N7OS/c1-29(2)18-7-9-30(10-8-18)16-19-15-21-23(34-19)24(31-11-13-33-14-12-31)28-25(27-21)32-17-26-20-5-3-4-6-22(20)32/h3-6,15,17-18H,7-14,16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assay				J Med Chem 55: 5887-900 (2012) Article DOI: 10.1021/jm3003747 BindingDB Entry DOI: 10.7270/Q2V125XN
					More data for this Ligand-Target Pair