BDBM50395335 CHEMBL2164387

SMILES: FC(F)(F)c1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c3ccccc23)cc1

InChI Key: InChIKey=TTZMPKHSTNMDRT-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50395335   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50395335 (CHEMBL2164387) Show SMILES FC(F)(F)c1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c3ccccc23)cc1 Show InChI InChI=1S/C24H20F3N3O2/c25-24(26,27)17-10-8-16(9-11-17)15-29-22(31)21-19-6-1-2-7-20(19)23(32)30(21)14-12-18-5-3-4-13-28-18/h1-11,13,21H,12,14-15H2,(H,29,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay				J Med Chem 55: 6866-80 (2012) Article DOI: 10.1021/jm300623u BindingDB Entry DOI: 10.7270/Q2M909SB
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50395335 (CHEMBL2164387) Show SMILES FC(F)(F)c1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c3ccccc23)cc1 Show InChI InChI=1S/C24H20F3N3O2/c25-24(26,27)17-10-8-16(9-11-17)15-29-22(31)21-19-6-1-2-7-20(19)23(32)30(21)14-12-18-5-3-4-13-28-18/h1-11,13,21H,12,14-15H2,(H,29,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay				J Med Chem 55: 6866-80 (2012) Article DOI: 10.1021/jm300623u BindingDB Entry DOI: 10.7270/Q2M909SB
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50395335 (CHEMBL2164387) Show SMILES FC(F)(F)c1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c3ccccc23)cc1 Show InChI InChI=1S/C24H20F3N3O2/c25-24(26,27)17-10-8-16(9-11-17)15-29-22(31)21-19-6-1-2-7-20(19)23(32)30(21)14-12-18-5-3-4-13-28-18/h1-11,13,21H,12,14-15H2,(H,29,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay				J Med Chem 55: 6866-80 (2012) Article DOI: 10.1021/jm300623u BindingDB Entry DOI: 10.7270/Q2M909SB
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50395335 (CHEMBL2164387) Show SMILES FC(F)(F)c1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c3ccccc23)cc1 Show InChI InChI=1S/C24H20F3N3O2/c25-24(26,27)17-10-8-16(9-11-17)15-29-22(31)21-19-6-1-2-7-20(19)23(32)30(21)14-12-18-5-3-4-13-28-18/h1-11,13,21H,12,14-15H2,(H,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay				J Med Chem 55: 6866-80 (2012) Article DOI: 10.1021/jm300623u BindingDB Entry DOI: 10.7270/Q2M909SB
					More data for this Ligand-Target Pair