BDBM50395348 CHEMBL2164366

SMILES: Fc1cnc(CCN2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c3ccccc3C2=O)nc1

InChI Key: InChIKey=LLBIIUQCQIOLNG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50395348   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50395348 (CHEMBL2164366) Show SMILES Fc1cnc(CCN2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c3ccccc3C2=O)nc1 Show InChI InChI=1S/C23H18F4N4O3/c24-15-12-28-19(29-13-15)9-10-31-20(17-3-1-2-4-18(17)22(31)33)21(32)30-11-14-5-7-16(8-6-14)34-23(25,26)27/h1-8,12-13,20H,9-11H2,(H,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay				J Med Chem 55: 6866-80 (2012) Article DOI: 10.1021/jm300623u BindingDB Entry DOI: 10.7270/Q2M909SB
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50395348 (CHEMBL2164366) Show SMILES Fc1cnc(CCN2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c3ccccc3C2=O)nc1 Show InChI InChI=1S/C23H18F4N4O3/c24-15-12-28-19(29-13-15)9-10-31-20(17-3-1-2-4-18(17)22(31)33)21(32)30-11-14-5-7-16(8-6-14)34-23(25,26)27/h1-8,12-13,20H,9-11H2,(H,30,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay				J Med Chem 55: 6866-80 (2012) Article DOI: 10.1021/jm300623u BindingDB Entry DOI: 10.7270/Q2M909SB
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50395348 (CHEMBL2164366) Show SMILES Fc1cnc(CCN2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c3ccccc3C2=O)nc1 Show InChI InChI=1S/C23H18F4N4O3/c24-15-12-28-19(29-13-15)9-10-31-20(17-3-1-2-4-18(17)22(31)33)21(32)30-11-14-5-7-16(8-6-14)34-23(25,26)27/h1-8,12-13,20H,9-11H2,(H,30,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay				J Med Chem 55: 6866-80 (2012) Article DOI: 10.1021/jm300623u BindingDB Entry DOI: 10.7270/Q2M909SB
					More data for this Ligand-Target Pair