BDBM50395724 CHEMBL2164103

SMILES: FC(F)(F)c1ccc(cc1)S(=O)(=O)NC[C@H]1CCCN1c1nc(NCC2CC2)nc(NCc2csc(n2)-c2cccs2)n1

InChI Key: InChIKey=GCCWHTUOVSYXKT-HXUWFJFHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50395724   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM50395724 (CHEMBL2164103) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)NC[C@H]1CCCN1c1nc(NCC2CC2)nc(NCc2csc(n2)-c2cccs2)n1 |r| Show InChI InChI=1S/C27H29F3N8O2S3/c28-27(29,30)18-7-9-21(10-8-18)43(39,40)33-15-20-3-1-11-38(20)26-36-24(31-13-17-5-6-17)35-25(37-26)32-14-19-16-42-23(34-19)22-4-2-12-41-22/h2,4,7-10,12,16-17,20,33H,1,3,5-6,11,13-15H2,(H2,31,32,35,36,37)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human ADAMTS-5 expressed in CHO cells using WAAG-3R as substrate preincubated for 15 mins measured after 1 hr by FRET assay				J Med Chem 55: 7061-79 (2012) Article DOI: 10.1021/jm300449x BindingDB Entry DOI: 10.7270/Q2RX9D6T
					More data for this Ligand-Target Pair